Objective Analyze the influence of 2 variables (post-traumatic growth and time since liver transplantation) on coping strategies used by the transplant recipient's family members. Methods In all, 218 family members who were their main caregivers of liver transplant recipients were selected. They were evaluated using the Posttraumatic Growth Inventory and the Brief COPE. A 3 × 3 factorial analysis of variance was used to analyze the influence that post-traumatic growth level (low, medium, and high) and time since transplantation (≤3.5 years, >3.5 to ≤9 years, and >9 years) exerted on caregiver coping strategies. Results No interactive effects between the two factors in the study were found. The only significant main effect was the influence of the post-traumatic growth factor on the following variables: instrumental support ( P = .007), emotional support ( P = .005), self-distraction ( P = .006), positive reframing ( P = .000), acceptance ( P = .013), and religion ( P = <.001). According to the most relevant effect sizes, low post-traumatic growth compared with medium growth was associated with less use of self-distraction ( P = .006, d = −0.52, medium effect size), positive reframing ( P = .001, d = −0.62, medium effect size), and religion ( P = .000, d = −0.66, medium effect size), and in comparison with high growth, it was associated with less use of positive reframing ( P = .002, d = −0.56, medium effect size) and religion ( P = .000, d = 0.87, large effect size). Conclusion Regardless of the time elapsed since the stressful life event (liver transplantation), family members with low post-traumatic growth usually use fewer coping strategies involving a positive, transcendent vision to deal with transplantation.