Objectives: To investigate the level of asthma control among children and to investigate the association between asthma control and the knowledge of caregivers. Methods: A cross-sectional study was conducted from January 2018 to July 2018 among 278 children with asthma aged 1-12 with their caregivers attending the primary health care centers in Al Madinah Al Munawarah, Saudi Arabia. An asthma knowledge questionnaire was used to measure the parents' knowledge.