At this point of time, two decades after intense biological research into dementia began, we need to reassess our perspective on hope, and understand the need for some redirection toward the larger questions of care when no cure is in sight. It does seem appropriate to focus more of our hope and possibly resources on care itself, and on the creation of attitudinal shifts toward the affirmation of the deeply forgetful. There is no compound available yet that promised to slow or cure dementia.