Aim: To examine caregiver burden of caregivers of patients with colorectal cancer. Method: This is a prospective, cross-sectional, descriptive study. The sample consisted of 162 patients who underwent colorectal cancer surgery between January 1 and June 30, 2015 in the General Surgery ward of Dokuz Eylül University Hospital. Data were collected using the Caregiver Strain Index (CSI) and the Your Reactions to Helping Your Family Member scale (RHFM), which is a component of the Family Care Inventory.