BACKGROUND: For family caregivers, sudden stroke events and heavy caring works are stressful events. At present, controversies about the factors affecting caregivers' stress response and their correlation with coping styles still exist. OBJECTIVE: To explore the influencing factors and coping styles of mental health stress responses of stroke caregivers and promote caregivers to adopt positive coping styles for diseases and caring works. METHODS: The convenience sampling method is used to select stroke caregivers as the research objects.