This study focused on out-of-pocket expenditures resulting from providing unpaid care to family members, friends, and neighbours. The main objective was to examine whether care-related out-of-pocket spending has a significant independent effect on caregiving consequences after controlling for the effects of other potential contributing factors. Cross-sectional data from the 2007 General Social Survey were used. Descriptive analyses and multivariate regression modeling were conducted. We found that an estimated 42.3% of the Canadian caregivers reported experiencing at least one of the six caregiving consequences. Results also showed that out-of-pocket spending was significantly associated with increased odds of caregiving consequences for men and women. This finding highlights the urgent need for policies and programs to support family/friend caregivers.