Objective: This study aims to identify the informal caregivers' difficulties in assisting the elderly patients of the Programa Saúde da Família [Family Health Program] in Bambuí city, Minas Gerais State, Brazil. Methods: This is a transversal research, approved by the Certificado de Apresentação para Apreciação Ética (CAAE) [Certificate of Presentation for Ethical Appreciation] No. 0146.0.213.000-11. Seventy elderly people and their informal caregivers were interviewed and the collected data were analyzed. Results: The treatment of cognitive disorders in the elderly (32.9%) and the lack of knowledge about the health care delivered (20%) were the main difficulties stated by the caregivers. These results also showed a bivariate relationship with "difficulty during care": the caregivers who stated that they slept less (≤ 6 hours/night) (%), "did not have a caregiver course" (%) and did not have "leisure activity" (%); regression: individuals who affirmed that they had not completed a course for caregivers of the elderly. Conclusion: It was settled that actions aiming to support the informal caregiver in face of the numerous difficulties faced in the care of the elderly are essential.