Introduction: We aimed to evaluate the emotional state and quality of life of family caregivers of stroke patients and to investigate the relationship between patient factors and these characteristics of caregivers. Materials and Method: Ninety-seven patients with hemiplegia after a cerebrovascular event and their caregivers were included in this cross-sectional study. The emotional state of the caregivers was evaluated with the Hospital Anxiety and Depression Scale (HADS). Their quality of life was evaluated with Short Form- 36. Functional Independence Measurement (FIM) and modified-Rankin Score (MRS) were used for functional status of the patients, HADS was used for their emotional state and Stroke-Specific Quality of Life Scale (SS-QOL) was used for their quality of life. Results: Mean HADS-Anxiety score was 9.0 ± 3.7 and mean HADS-Depression score was 8.3 ± 3.7 in caregivers. Mean HADS-Anxiety score was 10.1 ± 3.4 and mean HADS-D score was 8.7 ± 3.6 in patients. The rates of anxiety disorder and depression in caregivers were 39.2% and 55.7%, respectively. The rates of anxiety disorder and depression in stroke patients were 40.2% and 50.5%, respectively. A positive correlation was found between HADS scores of caregivers and patients (p < 0.05). There was a significant negative correlation between the HADS scores of caregivers and SS-QOL scores of patients (p < 0.05). There was a statistically significant relationship between the quality of life of caregivers and the MRS, motor FIM and FIM-total scores of patients (p < 0.05). Conclusion: As a result, mood disorders were common in stroke patients and their caregivers. Quality of life of caregivers was decreased. There was a relationship between the emotional state of patients and caregivers.