Background: Caregivers of older adults with chronic illnesses often face challenges that harm their health and well-being. Evidence-based strategies are needed to address such outcomes. Objectives: The current study aims to synthesize interventions designed to improve the health and well-being of caregivers of older adults with chronic illnesses. Methods: Search strategies included investigating four databases (e.g., PubMed, CINAHL), as well as conducting bibliographic, hand, and author searches. Eligible studies were randomized controlled trials conducted between 2009 and 2019 that included family caregivers of older adults with chronic illnesses aged =65 and that reported caregiver health or well-being outcomes. Results: Data from 24 eligible studies were extracted, analyzed, and narratively synthesized. Conclusions: Although intervention characteristics were diverse (e.g., strategies, interventionists), most improved health and well-being. Thus, providers have an array of interventions available to them to help caregivers. Future caregiver research should examine theory-driven interventions among diverse samples, clearly report intervention dose, and measure physical health.