Purpose: This study was aimed to examine the prevalence and factors associated with psychological distress among Saudi family caregivers. Design and Methods: This was a cross‐sectional, descriptive correlational study conducted on 163 participants. The Kessler Psychological Distress Scale‐6 was used to collect data. Bivariate and multivariate analyses were run in SPSS. Findings: Results indicated that psychological distress was significantly associated with employment status, education level, monthly money spent on caring, time spent on caregiving, and chronic disease type variables. Practice Implications: Implementing effective programs to raise family caregivers' understanding of psychological distress and improve their engagement in treatment is important.