Objective Studies on informal caregiving for older persons in Ghana have only reported the challenges of the caregivers without providing their coping mechanisms. Considering the myriad of challenges facing informal caregivers in Ghana, we sought to explore the coping mechanisms utilised by informal caregivers in rural and urban settings of Ghana to overcome their caregiving challenges. Methods In-depth interviews were conducted with 20 purposively selected caregivers from the Ejisu-Juaben Municipality and Kumasi Metropolis in the Ashanti Region of Ghana.