Background: Dementia is a progressive disease that puts substantial strain on caregivers. Many persons with dementia (PwDs) receive care from a relative. Since male and female caregivers experience different issues related to stress, it is important to meet their different needs to prevent the early nursing home placement of PwDs. Objectives: This study investigated the multifactorial aspects of caregiver burden and explored gender differences in caregiver burden in a rural setting.