Background & Objective: The family caregivers of patients with chronic obstructive pulmonary disease (COPD) experience heavy caregiver burden (CB). This study investigated the effects of a multidisciplinary supportive program on CB in the family caregivers of patients with advanced COPD. Materials & Methods: This randomized field trial was conducted in the pulmonary subspecialty clinic of Birjand University of Medical Sciences, in 2019.