Objective Investigate effectiveness of a 5-session manualized intervention for addressing needs of caregivers of persons in acute traumatic brain injury (TBI) rehabilitation. Design Prospective, pilot randomized controlled trial. Setting Inpatient brain injury rehabilitation unit, level 1 trauma center. Participants Patients (N=93) with moderate-to-severe TBI and their family members were enrolled in the study with 42 randomized to the treatment group, 51 to the control group.