Objectives: •Compare the experiences of burden for family caregivers in general to that of caregivers for patients with advanced cancer. • Evaluate patient-related factors that contribute to burden among caregivers for advanced cancer patients. • Assess how the relationship between patient-related factors and caregiver burden is affected by time spent caregiving. Importance: Family caregivers for patients with advanced cancer spend significant time caregiving and experience burden that has been associated with poor outcomes.