Objectives: To explore the effect of care transitions intervention (CTI) on the sense of benefit-finding of caregivers for patients with acute cerebral infarction (ACI). Ninety caregivers for patients with ACI were divided into two groups according to the random number table method (n = 45 in each group). Methods: The control group was given regular health guidance, and the intervention group was given care transitions intervention on the basis of the guidance used in the control group.