Objective: To review characteristics and experiences of informal cancer caregivers.; Data Sources: Recent empirical studies and review papers on informal cancer caregiving.; Conclusion: Increasing cancer prevalence and shifts toward outpatient care place substantial burden on caregivers. Cancer progression, treatment, and individual characteristics influence the caregiving experience. Longitudinal research and the development, testing, and implementation of effective interventions for cancer caregivers are needed.; Implications For Nursing Practice: Nurses play key roles in efforts to support cancer caregivers. Nursing interventions that incorporate caregiver preparation, support, and training in caregiving tasks are warranted.