The relationship between grief and depression in caregivers of individuals with Alzheimer's disease has not been clearly defined through empirical research. This pilot study examined the relationship between these two variables and determined the strength of their relationship. A racially diverse sample of caregivers was drawn from an urban setting on the east coast of the United States. Results indicated not only that a significant proportion of caregivers experience high levels of grief that may place them at risk of other difficulties, but also that grief is a significant predictor of increased depressive symptoms. Clinical social work implications are examined.