Objective: The study's main purpose has been to verify the profile of musculoskeletal disorders, emotional burden and health profile of caregivers of people bearing central nervous system injury sequelae. Methods: It is a descriptive study with 23 participating caregivers. There were applied musculoskeletal injury tests (Nordic Musculoskeletal Questionnaire), overload tests (Caregiver Burden Scale) and the Physical Mobility and Transfer Risk Assessment Scale. Results: The caregivers' profile were as follows: average age of 52.9 years old, women, spouses, elementary school, responsible for providing care to the patient, residence without a salary, and an average working hours of 15.8 hours per day. A total of 47.8% received little guidance on how to provide care services. Older people suffer more with pain (spine and upper limbs) and stay more away from activities from activities compared to younger ones (p-value = 0.01). Overall tension, isolation, and emotional burden were impactful (p-value = 0.03). Conclusion: The caregivers are family members, low income, have musculoskeletal pain, considerable emotional burden and physical pain, as well as they need support from the health team.