A breast cancer diagnosis presents daunting challenges and disruptions to everyday life for family members and caregivers of breast cancer survivors (BCS). Particularly critical to families are their coping mechanisms, patterns of resiliency, and resource availability to navigate such a transformational experience. Family therapy and family therapists can introduce vulnerable families to a variety of clinical interventions that can be helpful in reducing the distress engendered by a breast cancer diagnosis. This manuscript describes clinical dynamics, considerations, and interventions that can be utilized with families of breast cancer survivors. Implications for practice, limitations, and ideas for future research are discussed.