There are few formal outreach and out-patient support services to help family caring for older adults who have had a stroke in developing countries. Family caregivers experience negative changes in their quality of life. To assess quality of life perceptions of spouse and non-spouse caregivers of older adult stroke survivors. A longitudinal survey study. A convenience sample of forty-eight family caregivers was recruited from the Special Care Stroke Unit at a University Hospital in South Brazil. Quality of life was measured using the World Health Organization's Quality of Life BREF survey upon discharge from the hospital (Time 1) and two months after (Time 2). Non-spouse caregivers had the lowest Social Relationship scores at Time 1 (p <.001) and at Time 2 (p =.005), both in terms of personal relationship, the quality of their sex lives and support received from others. Unfortunately, formal community support programs for family caregivers in Brazil are lacking. Post-stroke caregiving is largely a family affair. Quality of Life assessments among family caregivers of older adult stroke survivors are crucial, particularly after discharge.