Background: The consequences of a brain injury can introduce ripple effects within a family for years after the initial event. Objectives: In this study, we focused on the experiences of couples negotiating their relationship after stroke. Methods: We specifically concentrated on the changes to couples' interdependence and the relational ramifications of those changes. Findings: Interview data from 41 participants (including 20 people who have had a stroke and 21 caregiving partners) suggest that as individuals noticed changes in themselves and their partner, they also noted significant changes within their relationship. As couples encountered their new relational dynamic, they had to manage various struggles including how to provide assistance, how to communicate effectively, and how to reframe their situation. Conclusions: Overall, couples relayed a trajectory of post-stroke life that involved a level of mutual influence that did not seem to exist prior to stroke.