Background: Taking care of a person with a physical disability can become a challenge for caregivers as they must combine the task of caring with their personal and daily needs. Objectives: The aim of this study was to assess the impact that taking care of a person who needs support has on caregivers and to analyze certain characteristics they present, such as self-esteem and resilience. Methods: To that end, a bibliographic review was carried out from 1985, when the first article of taking care of a person who needs support was published, to 2020 (inclusive), in the databases of Web of Science (WoS), Scopus, Pubmed, Eric, Psycinfo, and Embase. Results: The search yielded a total of (n = 37) articles subject to review, following the guidelines established in the PRISMA declaration. Conclusions: The results show that caregiving was highly overburdening and negatively affected the physical condition and the psychological and mental states of caregivers. In addition, certain psychological characteristics present in caregivers such as having high self-esteem and being resilient were found to act as protective factors against the caregiving burden.